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Dr. Cornelius, one of the senior scientists for Weapon X, is employed by the mysterious Professor Thornton. Some time after World War II, Wolverine is taken in by the project and Cornelius is assigned with the task of perfecting and using a technique that would bond the indestructible alloy adamantium to human bone cells. This adamantium-bonding process was first created by Lord Dark Wind (Lady Deathstrike's father), but is only put into use after being perfected by Cornelius when he succeeds in bonding Logan's skeleton with adamantium, after which Logan is indoctrinated into the Weapon X assassin program.

Years later, Japanese crimelord Matsu'o Tsurayaba and his allies, including former Weapon X scientist Doctor Cornelius, resurrect the Russian super-soldier Omega Red. In order to stabilize his mutant power, Omega Red requires the Carbonadium Synthesizer, a device stolen from him by Team X decades earlier. Omega Red captures Wolverine, who had the location of the C-Synthesizer buried in his memory, and several of Wolverine's teammates in the X-Men. Maverick is hired by former Team X liaison Major Arthur Barrington to prevent Omega Red from obtaining the device, and he tracks another former Team X member, Sabretooth, to Omega Red's location. With Maverick's help, the X-Men are able to defeat the villains. In the final confrontation between the Hand and Wolverine Cornelius is killed by Maverick.